PCB-47, PBDE-47, and 6-OH-PBDE-47 Differentially Modulate Human GABAA and α4β2 Nicotinic Acetylcholine Receptors
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چکیده
منابع مشابه
PCB-47, PBDE-47, and 6-OH-PBDE-47 Differentially Modulate Human GABAA and a4b2 Nicotinic Acetylcholine Receptors
Polychlorinated biphenyls (PCBs) and the structurally related polybrominated diphenyl ethers (PBDEs) are abundant persistent organic pollutants that exert several comparable neurotoxic effects. Importantly, hydroxylated metabolites of PCBs and PBDEs have an increased neurotoxic potency. Recently, we demonstrated that PCBs can act as (partial) agonist on GABAA neurotransmitter receptors, with PC...
متن کاملPCB-47, PBDE-47, and 6-OH-PBDE-47 differentially modulate human GABAA and alpha4beta2 nicotinic acetylcholine receptors.
Polychlorinated biphenyls (PCBs) and the structurally related polybrominated diphenyl ethers (PBDEs) are abundant persistent organic pollutants that exert several comparable neurotoxic effects. Importantly, hydroxylated metabolites of PCBs and PBDEs have an increased neurotoxic potency. Recently, we demonstrated that PCBs can act as (partial) agonist on GABA(A) neurotransmitter receptors, with ...
متن کاملThe PBDE metabolite 6-OH-BDE 47 affects melanin pigmentation and THRβ MRNA expression in the eye of zebrafish embryos
Polybrominated diphenyl ethers and their hydroxyl-metabolites (OH-BDEs) are commonly detected contaminants in human serum in the US population. They are also considered to be endocrine disruptors, and are specifically known to affect thyroid hormone regulation. In this study, we investigated and compared the effects of a PBDE and its OH-BDE metabolite on developmental pathways regulated by thyr...
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2,2',4,4'-Tetrabromodiphenyl ether (BDE-47), 6-hydroxy-tetrabromodiphenyl ether (6-OH-BDE-47), and 6-methoxy-tetrabromodiphenyl ether (6-MeO-BDE-47) are the most detected congeners of polybrominated diphenyl ethers (PBDEs), OH-BDEs, and MeO-BDEs, respectively, in aquatic organisms. Although it has been demonstrated that BDE-47 can interfere with certain endocrine functions that are mediated thr...
متن کاملACELL June 47/6
Eddinger, T. J., A. A. Korwek, D. P. Meer, and J. J. Sherwood. Expression of smooth muscle myosin light chain 17 and unloaded shortening in single smooth muscle cells. Am J Physiol Cell Physiol 278: C1133–C1142, 2000.—These experiments were performed to test the hypotheses that myosin light chain 17 (MLC17) a and b isoform expression varies between individual vascular smooth muscle (SM) cells a...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2010
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfq284